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Fundamentals of Epigenetics provides concise yet complete information on the many aspects of the basic and most recent concepts in epigenetics, a branch of life science that deals with the mechanisms such as DNA modifications, histone modifications, RNA modifications, small and long non-coding RNAs, chromatin remodelling, which are involved in epigenetic control of gene expression without involving variations in DNA sequences. These regulatory mechanisms lead to phenotypic variations. These epigenetic mechanisms can be exploited for crop improvement and cure of human diseases.
This book is primarily designed as a textbook for undergraduate and graduate level students studying epigenetics in conventional, agricultural and medicinal universities. Teachers and researchers in any discipline of life sciences, agricultural sciences, medicine, and biotechnology, molecular epigenetics and biotechnology will also find it useful as a reference book.
1. Introduction to Epigenetics
2. DNA Modifications
3. Histone Modifications
4. Functions of Histone Modifications
5. DNA, Histone and Nonhistone Protein Modifications in Gene Expression
6. RNA Modifications in Gene Expression
7. Epigenetic Modifiers
8. Epigenetic Crosstalk and Epigenetic Signals
9. Epigenetic Inheritance
10. Long and Small Non-coding RNAs
11. MicroRNAs and Short Interfering RNAs
12. RNA-Directed DNA Methylation and Epigenetic Reprogramming, Learning and Memory
13. Chromatin Remodelling
14. Epigenetic Control of Gene Expression
15. RNA Interference
16. Epigenetic Gene Silencing
17. Epigenetics in Crop Improvement
Gurbachan S. Miglani :- retired in 2005 as Professor of Genetics from Department of Plant Breeding, Genetics and Biotechnology, Punjab Agricultural University (PAU), Ludhiana, India after putting in 35 years of service. Taught general genetics, advanced genetics, biotechnology, biochemical genetics, molecular genetics, mutagenesis, immunogenetics, developmental genetics, and evolution to undergraduate and graduate students of constituent colleges of the PAU. Also taught genetics and zoology to undergraduates (September 1976-June 1980) at Howard University, Washington, D.C., USA, as a Graduate Teaching Assistant.
Professor Miglani was invited by School of Agricultural Biotechnology, PAU in March 2010 as Adjunct Professor, to teach molecular genetics, epigenetics and biotechnology to B.Sc. (Biotechnology)/B.Sc. Technology (Biotechnology), M.Sc. (Biotechnology) and Ph.D. (Biotechnology) students, which he continued till December 2010. He was rehired by PAU in January 2011 as Visiting Professor and he worked in this capacity till August 2020. He takes keen interest in popularization of science of genetics by way of radio talks and writing popular articles for magazines and newspapers. During last 11 years he has focused on writing of books, review papers and book chapters.
He has been associated with The Journal of Plant Science Research, published by the Society for the Promotion of Plant Science Research, Jaipur (India), for more than 12 years in different capacities, including editor of the journal. He is recipient of Meritorious Teacher Award of the PAU, Ludhiana, India, for the year 1997-98) and Sneh Prabha Shukla Memorial Award of Honor by Punjab Sahitya Kala Manch (Regd.), Ludhiana, Punjab, India for the year 2001.
He has guided twelve M.Sc. and one Ph.D. students and completed two prestigious research projects funded by the University Grants Commission, New Delhi, India. He has authored more than 175 publications (including research papers, review papers, books, book chapters, short notes/communications, abstracts, popular science articles) in Indian and foreign journals/magazines. Six laboratory manuals authored by him for different genetics courses and were published by the Punjab Agricultural University, Ludhiana, India. Contributed several chapters for books edited by Indian and foreign authors. He has also authored a 14 books - Dictionary of Plant Genetics and Molecular Biology (1998), Basic Genetics (2000), Advanced Genetics First edition (2002), Developmental Genetics (2006), Advanced Genetics Second Edition (2007), Fundamentals of Genetics (2008), Genetic Material (2013), Gene Regulation (2013) Gene Expression (2014), Essentials of Molecular Genetics (2015), Genetic Engineering: Principles, Procedures and Consequences (2016), Plant Cells and their Organelles (2017), Cryptic Variants at the Adh Locus in Drosophila melanogaster (2018), and Genome Editing: A Comprehensive Treatise (2019). All these books have been well received by the scientific community.