Development is behind what one looks like. It is directed by genes, the units of heredity, which are made up to deoxyribonucleic acid (DNA) in all animals (including man), plants, microorganisms and most of the viruses except in some viruses where ribonucleic acid (RNA) is the genetic material. Developmental Genetics integrates the two disciplines of development and genetics into one.
This book is essential reading for postgraduate in developmental genetics, teachers teaching this subject and developmental biologists conducting research in this area. It is also suitable for candidates preparing for ARS/UGC NET examination.
: 1. Introduction: Preformation versus Epigenesis *Ontogeny, Phylogeny and Recapitulation *Mosaic and Regulation Eggs *Genetics *Development *Developmental Genetics *Steps in Development *Role of Genes in Development *Understanding Development in Genetics Terms 2. Inheritance of Developmental Difference: Early Ideas about Heredity *Continuity of Life *Qualitative and Quantitative Traits *Genotype and Environmental Variation *Mendelian Principles *Concepts of Dominance *Heterosis and Hybrid Vigour *Reverse Genetics in Mendel’s Wrinkled Character *Molecular basis of Mendelian Genetics *Mendelism-An Exception or Rule *Mendel’s Results and Linkage *Chromosome Theory of Inheritance *Sex-Linked, Sex-Limited and Sex-Influenced Inheritance *Multiple Allelism *Gene-Gene Interactions *Tiem of Segregation *Endosperm Genetics *Mutations *Quantitative Traits *Penetrance and Expressivity *Pleiotropy *Phenocopies *Homestasis 3. Genome Constancy in Development: Totipotency *Exceptions in Genome Constancy 4. Nucleus and Nucleo-Cytoplasmic Interactions: Nucleus *Nucleo-cytoplasm Interactions 5. Gene-Protein-Phenotype Relationship: Chemical Nature of the Genetic Material *Molecular Structure of DNA *Molecular Structure of RNA *Properties of Genetic Material *DNA Replication *Biological Function of the Gene *Gene Expression *Analysis of Gene Expression *Environmental and Gene Expression *Types of Transcripts *Genetic Code *Protein Biosynthesis *Protein Targeting *Protein Secretion *Molecular Chaperone *Protein Turnover *Protein Degradation *Protein-Phenotype System 6. Gene Regulation and Differentiation: Gene regulation in Prokaryotes *Gene regulation in Lambda Phage *Gene regulation in Eukaryotes *Messenger RNA and Differentiation *Circadian Clock 7. Cells Development: Cell Cycle *Cell Proliferation *Cell Division Axis *Cell Elongation *Cell Determination and Differentiation *Transdetermination *Pattern Formation in Polytene Puffs *Trans differentiation *Cell Polarity *Cellular Homeostasis *Regulation of Diverse Cellular Activities *Cell and Tissue Regeneration *Cell Adhesion *Cell Commitment *Cell Migration *Cell Motility *Cellular Responses *Cell Competition *Intercellular Junctions *Cell-Cell Interaction *Cytoskelton 8. Cell-Specific Gene Activation and Tissue Differentiation: Origin of Different Cell Types *Cell-Specific Gene Activation *Specificity in Eukaryotic Transcription *Tissue Differentiation 9. Plant Embryology: Meiosis *Fertilization in Angiosperms *Endosperm Development *Embryo Formation *Storage Proteins 10. Gamete Formation, Fertilization and Cleavage in Animals: Primordial Germ Cells *Spermatogenesis *Oogenesis *Fertilization *Cleavage 11. Animal Development: Drosophila *Sea Urchin *Mammals *Frog *Caenorhabditis Elegans *Zebrafish *Blastogenesis *Bone Marrow Stem Cells 12. Dosage Compensation and Sex Determination: Dosage compensation *Mechanisms of Dosage Compensation *Sex Determination *Noncoding DNA Hypothesis for Sex-Determination *Evolutionary Relationships Among Sex-Determining Mechanisms *Sex Differentiation *Events in Sex Determination 13. Ageing and Apoptosis: Agening *Theories of Ageing *Genetics of Ageing *Postponement of Ageing *Apoptosis *Reaper Model *Regulators of Apoptosis *Miotchondrial Pathways of Apoptosis *Role Morphogens in Apoptosis *Programmed Cell Death in Plants 14. Pattern Formation and Epigenetics: Pattern Formation *Positional Information and Developmental Patterns *Epigenetics *DNA Methylation and Epigenetics *Epigenetic Reprogramming *Linking Conventional Genetics with Development *Epigenetic Code 15. Morphogenesis: Morphogens *Morphogenesis in Viruses *Morphogenesis in Bacillus Subtilis *Morphogenesis in Slime Mold *Morphogenesis in Green Algae *Morphogenesis in Animals *Binary Switch Genes *Process of Morphogenesis *Organ Development *Plant Morphogenesis 16. Homeosis: Drosophila Homeosis *Silkworm Homeosis *Tribolium Homeosis *Mode of Action of Specification *Common Codin
Gurbachan S. Miglani :- retired in 2005 as Professor of Genetics from Department of Plant Breeding, Genetics and Biotechnology, Punjab Agricultural University (PAU), Ludhiana, India after putting in 35 years of service. Taught general genetics, advanced genetics, biotechnology, biochemical genetics, molecular genetics, mutagenesis, immunogenetics, developmental genetics, and evolution to undergraduate and graduate students of constituent colleges of the PAU. Also taught genetics and zoology to undergraduates (September 1976-June 1980) at Howard University, Washington, D.C., USA, as a Graduate Teaching Assistant.
Professor Miglani was invited by School of Agricultural Biotechnology, PAU in March 2010 as Adjunct Professor, to teach molecular genetics, epigenetics and biotechnology to B.Sc. (Biotechnology)/B.Sc. Technology (Biotechnology), M.Sc. (Biotechnology) and Ph.D. (Biotechnology) students, which he continued till December 2010. He was rehired by PAU in January 2011 as Visiting Professor and he worked in this capacity till August 2020. He takes keen interest in popularization of science of genetics by way of radio talks and writing popular articles for magazines and newspapers. During last 11 years he has focused on writing of books, review papers and book chapters.
He has been associated with The Journal of Plant Science Research, published by the Society for the Promotion of Plant Science Research, Jaipur (India), for more than 12 years in different capacities, including editor of the journal. He is recipient of Meritorious Teacher Award of the PAU, Ludhiana, India, for the year 1997-98) and Sneh Prabha Shukla Memorial Award of Honor by Punjab Sahitya Kala Manch (Regd.), Ludhiana, Punjab, India for the year 2001.
He has guided twelve M.Sc. and one Ph.D. students and completed two prestigious research projects funded by the University Grants Commission, New Delhi, India. He has authored more than 175 publications (including research papers, review papers, books, book chapters, short notes/communications, abstracts, popular science articles) in Indian and foreign journals/magazines. Six laboratory manuals authored by him for different genetics courses and were published by the Punjab Agricultural University, Ludhiana, India. Contributed several chapters for books edited by Indian and foreign authors. He has also authored a 14 books - Dictionary of Plant Genetics and Molecular Biology (1998), Basic Genetics (2000), Advanced Genetics First edition (2002), Developmental Genetics (2006), Advanced Genetics Second Edition (2007), Fundamentals of Genetics (2008), Genetic Material (2013), Gene Regulation (2013) Gene Expression (2014), Essentials of Molecular Genetics (2015), Genetic Engineering: Principles, Procedures and Consequences (2016), Plant Cells and their Organelles (2017), Cryptic Variants at the Adh Locus in Drosophila melanogaster (2018), and Genome Editing: A Comprehensive Treatise (2019). All these books have been well received by the scientific community.