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This book contains ten chapters which cover current trends on antibiotic resistance in different parts of the world. Some of the chapters are dedicated to specific type of bacteria like marine and cholera associated microorganisms. Whereas rest of the chapters are mainly focused on the mechanism of drug resistance with special reference to beta lactamases. Since most of the antibiotics used to treat infections belong to -lactam group which is lactam ring (β-lactam) or penam is a lactam with a heteroatomic ring structure, consisting of three carbon atoms and one nitrogen atom. A lactam is a cyclic amide.
The main focus of this book is to understand the different molecular markers responsible for developing resistance against this group of antibiotics. CTX-M family of enzyme which hydrolyzes third generation of cephalosporins preferably, cefotaxime, belongs to the category of Extended-spectrum -lactamases (ESBLs). These types of enzymes are emerging among Gram-negative bacteria; predominantly Klebsiella pneumoniae, Escherichia coli and other species in different parts of the world. In the current scenario, the CTX-M family includes almost 40 variants. The blaTEM, and blaSHV are another important class of -lactamases, most prevalent among enterobacteriacae which are also discussed in this book.
1. Quorum-Sensing and Multiple Antibiotic Resistance 2. Genes Encoding Production of Metallo-Β-Lactamases in Most Important Gram-Negative Pathogens 3. Ciprofloxacin Resistance Among Uropathogens 4. Metallo-Β-Lactamase-Producing Klebsiella Pneumoniae 5. Drug Resistance in Marine Bacteria 6. An Overview of the Carbapenems with a Focus on Doripenem—The Latest Member of The Carbapenem Class. 7. Increasing Importance of Newer Beta Lactamases in Indian 8. Vancomycin Resistant Staphylococcus Aureus: A Global Threat 9. Molecular Epidemiology of Ampc Beta-Lactamases 10. Cholera and the Acquisition of Antimicrobial Resistance
Asad U. Khan :- Molecular Biologist, graduated from Biochemistry Department, A M University, Aligarh, India in 1998. He joined Interdisciplinary Biotechnology Unit, A.M University as Asst Professor in 1997 and continued till 2000. He later joined Department of Biochemistry, UMDNJ, and New Jersey USA in 2000 for three years as post doctoral Research Associate. He is working on Gene expression and drug resistance. He then resumed his services as Asst. Professor in the same department till 2006 and became Associate Professor in the Interdisciplinary Biotechnology Unit, AMU. He was awarded a prestigious BOYSCAST Fellowship from Government of India to work as Visiting Scientist in University of Napoli, Italy in 2005. He was also awarded Young Scientist Award of Association of Microbiologist of India in 2006. His work was well recognized and he has been invited for several invited talks. He has been in Editorial board of several International journals.